The American Association for the Study of Liver Diseases (AASLD) has updated their Guidance with a key recommendation: elimination of an absolute serum creatinine (SCr) threshold for diagnosis of hepatorenal syndrome acute kidney injury (HRS-AKI / HRS-1). This Guidance, which aligns with a 2015 recommendation from the International Club of Ascites (ICA), may lead to earlier diagnosis and improved treatment outcomes.1-3
HRS-AKI / HRS-1:
New AASLD nomenclature and definition
Kidney Injury Definition
Previously known as
HRS-1:Doubling of SCr to a value >2.5 mg/dL within 2 weeks4
Now known as
HRS-AKI:Increase in SCr of ≥0.3 mg/dL within 48 hours1
or
Percent increase in SCr that is ≥50% of what was known or presumed to have occurred within the prior 7 days1